Participating in clinical trials offers individuals the opportunity to access innovative treatments while contributing to medical research. Several clinical trials are currently recruiting participants to explore new therapies for depression. Below is an overview of some notable studies:
1. Study on NORA520 for Severe Postpartum Depression
This research aims to evaluate the efficacy and safety of NORA520 as a potential treatment for severe postpartum depression (PPD). The objectives include:
• Assessing the tolerability and side effects of NORA520.
• Determining its impact on depressive symptoms in severe PPD cases.
• Measuring blood concentrations of NORA520 at various intervals post-administration to inform dosing schedules.
Eligible participants are females aged 18 to 45 years.
2. Vagus Nerve Stimulation (VNS) Therapy for Treatment-Resistant Depression
This trial investigates the safety and effectiveness of VNS Therapy® System as an adjunctive treatment compared to a no-stimulation control in individuals with treatment-resistant depression. The primary goal is to determine if active VNS Therapy leads to a significant reduction in depressive symptom severity over 12 months.
Adults aged 18 and older are eligible to participate. Recruitment is ongoing in multiple locations.
3. Psilocybin Research for Major Depressive Disorder
Segal Trials is conducting a study to assess the efficacy, tolerability, and safety of psilocybin in adults with Major Depressive Disorder (MDD). This psychedelic research aims to explore alternative treatment avenues for individuals who have not responded adequately to conventional therapies.
Participants must be 18 years or older.
4. Rapid Diagnosis of Mild Cognitive Impairment and Depression in Seniors
This study focuses on refining artificial intelligence tools to accurately detect and differentiate between mild cognitive impairment and late-life depression in individuals aged 60 and above. Early and precise diagnosis can lead to better management and treatment outcomes.
6. Major Depressive Disorder Clinical Trials at Segal Trials
Segal Trials offers multiple studies targeting Major Depressive Disorder, including:
• Adjunctive Treatment Studies: Evaluating the efficacy and safety of investigational drugs combined with standard antidepressants in adults aged 18 to 65.
• Inpatient Studies: Assessing new treatments for MDD in a controlled, inpatient setting.
Participants may receive compensation for their time and travel. Studies are conducted at various Segal Trials locations.
7. Fit2Play Prospective Cohort Study
This study examines the effects of a park-based afterschool physical activity program on youth fitness and mental health outcomes. Conducted in collaboration with Miami-Dade County Parks and Recreation, the research aims to promote mental well-being through physical activity.
Children aged 6 to 14 years are eligible.
8. Mental Health in Primary Care Study
This trial evaluates an enhanced version of eHealth Familias Unidas, aiming to reduce depressive and anxious symptoms, as well as suicidal behavior, in Hispanic youth. The study is implemented across 18 pediatric primary care clinics.
Eligible participants are adolescents aged 12 to 16 years.
9. Depression with Prescribed Antidepressant Study
This clinical trial seeks individuals aged 18 to 65 who are currently diagnosed with depression and are taking antidepressant medications but continue to experience symptoms. The study aims to evaluate additional treatment options to improve depressive symptoms.
Qualified participants will receive study-related exams, EKGs, and laboratory testing at no cost, along with compensation for time and travel.
10. Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
This study examines the effects of a park-based youth physical activity afterschool program on participants’ fitness and mental health outcomes.
Children aged 6 to 14 years are eligible to participate.
There are many resources to cite regarding clinical trials in your area.
Before deciding to participate, it’s essential to consult with healthcare professionals to determine eligibility. Our website is informational only and we do not provide medical opinions or advice.